Concepts
Landing page for wiki/concepts/ — cross-cutting concepts, staging systems, biomarkers, and
techniques that don’t belong to a single condition or procedure.
- Total Neoadjuvant Therapy (TNT) — neoadjuvant chemo+RT before surgery for locally advanced rectal cancer: efficacy/trade-offs, risk-stratified indications, regimen choice, non-operative management, adjuvant therapy guidance. Sourced from Boublikova 2023 - TNT in Rectal Cancer Review.
- Cytoreductive Surgery and HIPEC — CRS/HIPEC for peritoneal surface malignancy: PCI/CC scoring, outcomes for appendiceal PMP, controversies (PRODIGE 7, COLOPEC, PCI cutoffs, agent choice). Sourced from Hoehn 2021 - Appendiceal Neoplasms.
- Colorectal Cancer Molecular Pathways — chromosomal instability, CIMP, MSI mutator pathway, EMT, CMS1-4 consensus molecular subtypes. Sourced from Sabiston Ch52 - Colorectal Neoplasia & Colon Cancer Surgery (textbook reference).
- Colorectal Cancer Staging (TNM) — TNM/AJCC framework, clinical vs. pathologic staging, additional prognostic factors (CEA, LVI/PNI, CRM, tumor regression grade, molecular markers). Sourced from Sabiston Ch52 - Colorectal Neoplasia & Colon Cancer Surgery (textbook reference).
- Colorectal Anastomotic Complications — leaks/dehiscence, necrosis of transposed colon, bleeding, twisting, strictures; cross-cutting, not rectal-specific. Sourced from Sabiston Ch52 - Rectal Cancer Surgery (textbook reference).
- Anorectal Physiology Testing — manometry, balloon expulsion, pudendal nerve terminal motor latency, EMG, endoanal ultrasound, defecography, colonic transit study. Sourced from Sabiston Ch52 - Pelvic Floor Disorders & Constipation (textbook reference).
- Small Intestine Anatomy & Physiology — embryology; gross/neurovascular/microscopic anatomy; digestion/absorption physiology; motility (MMC); endocrine function; immune function (GALT). Sourced from Sabiston Ch50 - Small Bowel Anatomy, Physiology, Obstruction & Crohn Disease (textbook reference).